Karen Scott, MD, MPH

Employee of Contracting Firm
Ob/Gyn, Reproductive Sciences
+1 415 353-4649

At the University of California, San Francisco, Karen A. Scott, MD, MPH, FACOG is an Associate Professor and OBGYN Hospitalist in the Department of Obstetrics and Gynecology. As a sexual, reproductive, and perinatal (SRP) epidemiologist and obstetric hospitalist, the ethics and science of her research, clinical practice, and teaching exists at the intersections of critical, interpretative, cultural, and biomedical anthropology and crunk public health, with a foundation rooted in Cultural Rigor, Black Feminism, and Reproductive Justice (RJ).

As a "dissident, disruptive, and recovering" board certified OBGYN and critical public health scholar, her work examines interventions to eliminate and reduce disparities and inequities in SRP health services provision, through the integration of a Black Feminist and Reproductive Justice (RJ) Praxis , in the afterlife of slavery and passage of the Congressional Act of 1807 (which took effect in 1808, prohibiting further participation of the United States in the slave trade.). A Black Feminist-RJ Praxis informs the ethical considerations, theoretical concepts, methods, and methodologies in her participatory research, practice, pedagogy, and policy analysis. She examines health service provision in antepartum, intrapartum, and postpartum units as sites through which racism (structural, gendered, and obstetric) can be understood, described, measured, and modified within patient-clinician, patient-system, and community-system interactions, across time, place, and levels of power in the following continuum of care: clinical cognition, assessment, diagnosis, service provision, and decision-making processes. Her research also examines the role of gendered racism, power, and economics in the authentic, coerced, and regulated formations and expressions of Blackness, Black womanhood, Black motherhood, Black births, and Black women's scholarship within hospital and health systems culture, organizational structures, and operating mechanisms.

Inspired by Marshall, Pronovost, and Woods 2013 critical paper on the Promotion of Improvement as a Science and Deming’s System of Profound Knowledge (epistemology, variation, systems, and psychology), her participatory equity and justice based QI research aims to interrogate and dismantle traditional QI projects that rely on “contemporaneous, non-standardized unverified data to make judgments about their effectiveness” using atheoretical methods, at the exclusion and erasure of the wisdom and voices of the most impacted, marginalized, and minoritized patients, practitioners, and scholars. Her secondary research aim is to describe and amplify local wisdom and transferable knowledge with robust participatory research methods grounded in Cultural Rigor, Black Feminism, and Reproductive Justice, in order to facilitate local improvement in health systems and construct knowledge with external validity for, by, and with Black mothers, birthing, women-led/serving community-based organizations, and women scholars. The implications of her program of participatory QI research are three fold: 1) formation of authentic, affirming, and autonomous partnerships among community partners, patients, academic scholars, practitioners, payers, and policy makers; 2) theory of change development and clarification representing epistemological diversity from health services research, clinical epidemiology, medicine, nursing, public health, social sciences, humanities, bioethics, and legal studies; and 3) translation of participatory QI science into SRP health care services provision, interprofessional education, and policy at the local and national level.

As an educator, she examines the approachability, acceptability, availability and accommodation, affordability, and appropriateness of individuals, institutions, and systems in public health and health care that have traditionally rendered marginalized voices and communities invisible or invaluable as decision-makers, generative thinkers, achievers, and connectors. As a clinician scientist, she works to build individual and system capacity to challenge the hierarchy of knowledge production and dissemination as well as the decision making that sustains the medical industrial complex and perpetuates social and health inequities.

As the Principal Investigator of the SACRED Birth Study, she has defined three theoretical frameworks with the foal of redesigning perinatal QI through community driven measures, meanings, and methods: 1) sacred birth; 2) participatory QI research (QIR); and 3) participatory patient reported experience measure (PREM) of obstetric racism in partnership with Black birthing mothers and birthing people, Black women-led community based organizations, Black women scholars, and other scholar allies and accomplices, recently published in a public platform for greater accountability and dissemination to the public we serve.

She has also examined the role of philanthropy in advancing cultural arrogance, philanthropic redlining, and community harm in addressing the perinatal health crisis in the United States. In response to the crisis, she has described four modalities of cultural rigor and offered recommendations on the operationalization of cultural rigor, reproductive justice, and Black feminism for funders, grantees, research teams, and QI experts.

Publications: 

Alleviating hypertension by selectively targeting angiotensin receptor expressing vagal sensory neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Baumer-Harrison C, Elsaafien K, Johnson DN, Aponte JDP, de Araujo A, Patel S, Bruce E, Harden SW, Frazier CJ, Scott KA, de Lartigue G, Krause EG, de Kloet AD

Support for criminalization of self-managed abortion (SMA): A national representative survey.

Social science & medicine (1982)

Biggs MA, Becker A, Schroeder R, Kaller S, Scott K, Grossman D, Raifman S, Ralph L

Mechanosensation of the heart and gut elicits hypometabolism and vigilance in mice.

bioRxiv : the preprint server for biology

Scott KA, Tan Y, Johnson DN, Elsaafien K, Baumer-Harrison C, Eikenberry SA, Sa JM, de Lartigue G, de Kloet AD, Krause EG

FoxO1 regulates adipose transdifferentiation and iron influx by mediating Tgfβ1 signaling pathway.

Redox biology

Shi L, Tao Z, Zheng L, Yang J, Hu X, Scott K, de Kloet A, Krause E, Collins JF, Cheng Z

Community Support Persons and Mitigating Obstetric Racism During Childbirth.

Annals of family medicine

Lett E, Hyacinthe MF, Davis DA, Scott KA

Emotional safety is patient safety.

BMJ quality & safety

Lyndon A, Davis DA, Sharma AE, Scott KA

Clinicians' Perspectives on Racism and Black Women's Maternal Health.

Women's health reports (New Rochelle, N.Y.)

Chambers BD, Taylor B, Nelson T, Harrison J, Bell A, O'Leary A, Arega HA, Hashemi S, McKenzie-Sampson S, Scott KA, Raine-Bennett T, Jackson AV, Kuppermann M, McLemore MR

Oxytocin and cardiometabolic interoception: Knowing oneself affects ingestive and social behaviors.

Appetite

Smith JA, Eikenberry SA, Scott KA, Baumer-Harrison C, de Lartigue G, de Kloet AD, Krause EG

A Novel Organ-Specific Approach to Selectively Target Sensory Afferents Innervating the Aortic Arch.

Frontiers in physiology

Elsaafien K, Harden SW, Johnson DN, Kimball AK, Sheng W, Smith JA, Scott KA, Frazier CJ, de Kloet AD, Krause EG

Psychometric validation of a patient-reported experience measure of obstetric racism© (The PREM-OB Scale™ suite).

Birth (Berkeley, Calif.)

White VanGompel E, Lai JS, Davis DA, Carlock F, Camara TL, Taylor B, Clary C, McCorkle-Jamieson AM, McKenzie-Sampson S, Gay C, Armijo A, Lapeyrolerie L, Singh L, Scott KA

Risk of early birth by body mass index in a propensity score matched sample: a retrospective cohort study.

BJOG : an international journal of obstetrics and gynaecology

Baer RJ, Chambers BD, Coleman-Phox K, Flowers E, Fuchs JD, Oltman SP, Scott KA, Ryckman KK, Rand L, Jelliffe-Pawlowski LL

Targeting angiotensin type-2 receptors located on pressor neurons in the nucleus of the solitary tract to relieve hypertension in mice.

Cardiovascular research

Mohammed M, Johnson DN, Wang LA, Harden SW, Sheng W, Spector EA, Elsaafien K, Bader M, Steckelings UM, Scott KA, Frazier CJ, Sumners C, Krause EG, de Kloet AD

Conditioned social preference and reward value of activating oxytocin-receptor-expressing ventral tegmental area neurons following repeated daily binge ethanol intake.

Alcoholism, clinical and experimental research

Peris J, Totten K, Montgomery D, Lester H, Weatherington A, Piotrowski B, Sowell S, Doyle K, Scott K, Tan Y, MacFadyen KA, Engle H, de Kloet AD, Krause EG

The association of COVID-19 infection in pregnancy with preterm birth: A retrospective cohort study in California.

Lancet Regional Health. Americas

Karasek D, Baer RJ, McLemore MR, Bell AJ, Blebu BE, Casey JA, Coleman-Phox K, Costello JM, Felder JN, Flowers E, Fuchs JD, Gomez AM, Karvonen K, Kuppermann M, Liang L, McKenzie-Sampson S, McCulloch CE, Oltman SP, Pantell MS, Piao X, Prather AA, Schmidt RJ, Scott KA, Spellen S, Stookey JD, Tesfalul M, Rand L, Jelliffe-Pawlowski LL

Maternal nativity and risk of adverse perinatal outcomes among Black women residing in California, 2011-2017.

Journal of perinatology : official journal of the California Perinatal Association

McKenzie-Sampson S, Baer RJ, Blebu BE, Karasek D, Oltman SP, Pantell MS, Rand L, Rogers EE, Torres JM, Jelliffe-Pawlowski LL, Scott KA, Chambers BD

Early-life oxytocin attenuates the social deficits induced by caesarean-section delivery in the mouse.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Morais LH, Golubeva AV, Casey S, Scott KA, Ramos Costa AP, Moloney GM, Dinan TG, Cryan JF

Identification of Novel Cross-Talk between the Neuroendocrine and Autonomic Stress Axes Controlling Blood Pressure.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Elsaafien K, Kirchner MK, Mohammed M, Eikenberry SA, West C, Scott KA, de Kloet AD, Stern JE, Krause EG

Central and peripheral GLP-1 systems independently suppress eating.

Nature metabolism

Brierley DI, Holt MK, Singh A, de Araujo A, McDougle M, Vergara M, Afaghani MH, Lee SJ, Scott K, Maske C, Langhans W, Krause E, de Kloet A, Gribble FM, Reimann F, Rinaman L, de Lartigue G, Trapp S

Black Women's Perspectives on Structural Racism across the Reproductive Lifespan: A Conceptual Framework for Measurement Development.

Maternal and child health journal

Chambers BD, Arega HA, Arabia SE, Taylor B, Barron RG, Gates B, Scruggs-Leach L, Scott KA, McLemore MR

An Angiotensin-Responsive Connection from the Lamina Terminalis to the Paraventricular Nucleus of the Hypothalamus Evokes Vasopressin Secretion to Increase Blood Pressure in Mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Frazier CJ, Harden SW, Alleyne AR, Mohammed M, Sheng W, Smith JA, Elsaafien K, Spector EA, Johnson DN, Scott KA, Krause EG, de Kloet AD

Risk and Protective Factors for Preterm Birth Among Black Women in Oakland, California.

Journal of racial and ethnic health disparities

McLemore MR, Berkowitz RL, Oltman SP, Baer RJ, Franck L, Fuchs J, Karasek DA, Kuppermann M, McKenzie-Sampson S, Melbourne D, Taylor B, Williams S, Rand L, Chambers BD, Scott K, Jelliffe-Pawlowski LL

Preterm birth and nativity among Black women with gestational diabetes in California, 2013-2017: a population-based retrospective cohort study.

BMC pregnancy and childbirth

Scott KA, Chambers BD, Baer RJ, Ryckman KK, McLemore MR, Jelliffe-Pawlowski LL

Enduring Behavioral Effects Induced by Birth by Caesarean Section in the Mouse.

Current biology : CB

Morais LH, Golubeva AV, Moloney GM, Moya-Pérez A, Ventura-Silva AP, Arboleya S, Bastiaanssen TFS, O'Sullivan O, Rea K, Borre Y, Scott KA, Patterson E, Cherry P, Stilling R, Hoban AE, El Aidy S, Sequeira AM, Beers S, Moloney RD, Renes IB, Wang S, Knol J, Ross RP, O'Toole PW, Cotter PD, Stanton C, Dinan TG, Cryan JF

Reflecting on Equity in Perinatal Care During a Pandemic.

Health equity

Niles PM, Asiodu IV, Crear-Perry J, Julian Z, Lyndon A, McLemore MR, Planey AM, Scott KA, Vedam S

Overexpression of angiotensin converting enzyme 2 reduces anxiety-like behavior in female mice.

Physiology & behavior

de Kloet AD, Cahill KM, Scott KA, Krause EG

Racial and Ethnic Disparities in Hospital-Based Care Associated with Postpartum Depression.

Journal of racial and ethnic health disparities

Chan AL, Guo N, Popat R, Robakis T, Blumenfeld YY, Main E, Scott KA, Butwick AJ

Redesigning Perinatal Quality Improvement Initiative: Community Driven Measures, Meanings, and Methods

Redesigning Perinatal Quality Improvement Initiative: Community Driven Measures, Meanings, and Methods.

Scott KA

An anti-CRF antibody suppresses the HPA axis and reverses stress-induced phenotypes.

The Journal of experimental medicine

Futch HS, McFarland KN, Moore BD, Kuhn MZ, Giasson BI, Ladd TB, Scott KA, Shapiro MR, Nosacka RL, Goodwin MS, Ran Y, Cruz PE, Ryu DH, Croft CL, Levites Y, Janus C, Chakrabarty P, Judge AR, Brusko TM, de Kloet AD, Krause EG, Golde TE

Race, Research, and Women's Health: Best Practice Guidelines for Investigators.

Obstetrics and gynecology

McLemore MR, Asiodu I, Crear-Perry J, Davis DA, Drew M, Hardeman RR, Mendez DD, Roberts L, Scott KA

Consistency of Direct-to-Consumer Genetic Testing Results Among Identical Twins.

The American journal of medicine

Huml AM, Sullivan C, Figueroa M, Scott K, Sehgal AR

Mid-life microbiota crises: middle age is associated with pervasive neuroimmune alterations that are reversed by targeting the gut microbiome.

Molecular psychiatry

Boehme M, van de Wouw M, Bastiaanssen TFS, Olavarría-Ramírez L, Lyons K, Fouhy F, Golubeva AV, Moloney GM, Minuto C, Sandhu KV, Scott KA, Clarke G, Stanton C, Dinan TG, Schellekens H, Cryan JF

The Ethics of Perinatal Care for Black Women: Dismantling the Structural Racism in "Mother Blame" Narratives.

The Journal of perinatal & neonatal nursing

Scott KA, Britton L, McLemore MR

Racial and ethnic disparities in severe maternal morbidity prevalence and trends.

Annals of epidemiology

Leonard SA, Main EK, Scott KA, Profit J, Carmichael SL

Fourth ventricular thyrotropin induces satiety and increases body temperature in rats.

American journal of physiology. Regulatory, integrative and comparative physiology

Smedh U, Scott KA, Moran TH

Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics.

Nature reviews. Gastroenterology & hepatology

Gibson GR, Hutkins R, Sanders ME, Prescott SL, Reimer RA, Salminen SJ, Scott K, Stanton C, Swanson KS, Cani PD, Verbeke K, Reid G

Susceptibility or resilience? Prenatal stress predisposes male rats to social subordination, but facilitates adaptation to subordinate status.

Physiology & behavior

Scott KA, de Kloet AD, Smeltzer MD, Krause EG, Flak JN, Melhorn SJ, Foster MT, Tamashiro KLK, Sakai RR

Revisiting Metchnikoff: Age-related alterations in microbiota-gut-brain axis in the mouse.

Brain, behavior, and immunity

Scott KA, Ida M, Peterson VL, Prenderville JA, Moloney GM, Izumo T, Murphy K, Murphy A, Ross RP, Stanton C, Dinan TG, Cryan JF

A closer look at the subordinate population within the visible burrow system.

Physiology & behavior

Melhorn SJ, Elfers CT, Scott KA, Sakai RR

Stress coping style does not determine social status, but influences the consequences of social subordination stress.

Physiology & behavior

Boersma GJ, Smeltzer MD, Scott KA, Scheurink AJ, Tamashiro KL, Sakai RR

Transferring the blues: Depression-associated gut microbiota induces neurobehavioural changes in the rat.

Journal of psychiatric research

Kelly JR, Borre Y, O' Brien C, Patterson E, El Aidy S, Deane J, Kennedy PJ, Beers S, Scott K, Moloney G, Hoban AE, Scott L, Fitzgerald P, Ross P, Stanton C, Clarke G, Cryan JF, Dinan TG

Chronic P-glycoprotein inhibition increases the brain concentration of escitalopram: potential implications for treating depression.

Pharmacology research & perspectives

O'Brien FE, Moloney GM, Scott KA, O'Connor RM, Clarke G, Dinan TG, Griffin BT, Cryan JF

Altered Colonic Bacterial Fermentation as a Potential Pathophysiological Factor in Irritable Bowel Syndrome.

The American journal of gastroenterology

Ringel-Kulka T, Choi CH, Temas D, Kim A, Maier DM, Scott K, Galanko JA, Ringel Y

Adipocyte glucocorticoid receptors mediate fat-to-brain signaling.

Psychoneuroendocrinology

de Kloet AD, Krause EG, Solomon MB, Flak JN, Scott KA, Kim DH, Myers B, Ulrich-Lai YM, Woods SC, Seeley RJ, Herman JP

Thinking small: towards microRNA-based therapeutics for anxiety disorders.

Expert opinion on investigational drugs

Scott KA, Hoban AE, Clarke G, Moloney GM, Dinan TG, Cryan JF

Amylin blunts hyperphagia and reduces weight and fat gain during recovery in socially stressed rats.

American journal of physiology. Regulatory, integrative and comparative physiology

Smeltzer M, Scott K, Melhorn S, Krause E, Sakai R

Effects of Chronic Social Stress on Obesity.

Current obesity reports

Scott KA, Melhorn SJ, Sakai RR

Blood-borne angiotensin II acts in the brain to influence behavioral and endocrine responses to psychogenic stress.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Krause EG, de Kloet AD, Scott KA, Flak JN, Jones K, Smeltzer MD, Ulrich-Lai YM, Woods SC, Wilson SP, Reagan LP, Herman JP, Sakai RR

Central angiotensin II has catabolic action at white and brown adipose tissue.

American journal of physiology. Endocrinology and metabolism

de Kloet AD, Krause EG, Scott KA, Foster MT, Herman JP, Sakai RR, Seeley RJ, Woods SC

Obesity/hyperleptinemic phenotype adversely affects hippocampal plasticity: effects of dietary restriction.

Physiology & behavior

Grillo CA, Piroli GG, Evans AN, Macht VA, Wilson SP, Scott KA, Sakai RR, Mott DD, Reagan LP

Meal patterns and hypothalamic NPY expression during chronic social stress and recovery.

American journal of physiology. Regulatory, integrative and comparative physiology

Melhorn SJ, Krause EG, Scott KA, Mooney MR, Johnson JD, Woods SC, Sakai RR

Glucose parameters are altered in mouse offspring produced by assisted reproductive technologies and somatic cell nuclear transfer.

Biology of reproduction

Scott KA, Yamazaki Y, Yamamoto M, Lin Y, Melhorn SJ, Krause EG, Woods SC, Yanagimachi R, Sakai RR, Tamashiro KL

Acute exposure to a high-fat diet alters meal patterns and body composition.

Physiology & behavior

Melhorn SJ, Krause EG, Scott KA, Mooney MR, Johnson JD, Woods SC, Sakai RR

Role of dorsomedial hypothalamic neuropeptide Y in modulating food intake and energy balance.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Yang L, Scott KA, Hyun J, Tamashiro KL, Tray N, Moran TH, Bi S

Angiotensin type 1 receptors in the subfornical organ mediate the drinking and hypothalamic-pituitary-adrenal response to systemic isoproterenol.

Endocrinology

Krause EG, Melhorn SJ, Davis JF, Scott KA, Ma LY, de Kloet AD, Benoit SC, Woods SC, Sakai RR

Leptin activates hypothalamic acetyl-CoA carboxylase to inhibit food intake.

Proceedings of the National Academy of Sciences of the United States of America

Gao S, Kinzig KP, Aja S, Scott KA, Keung W, Kelly S, Strynadka K, Chohnan S, Smith WW, Tamashiro KL, Ladenheim EE, Ronnett GV, Tu Y, Birnbaum MJ, Lopaschuk GD, Moran TH

The GLP-1 agonist exendin-4 reduces food intake in nonhuman primates through changes in meal size.

American journal of physiology. Regulatory, integrative and comparative physiology

Scott KA, Moran TH

Eosinophilic airway disorders.

Seminars in respiratory and critical care medicine

Scott KA, Wardlaw AJ

Lateral ventricular ghrelin and fourth ventricular ghrelin induce similar increases in food intake and patterns of hypothalamic gene expression.

American journal of physiology. Regulatory, integrative and comparative physiology

Kinzig KP, Scott KA, Hyun J, Bi S, Moran TH

Dorsomedial hypothalamic corticotropin-releasing factor mediation of exercise-induced anorexia.

American journal of physiology. Regulatory, integrative and comparative physiology

Kawaguchi M, Scott KA, Moran TH, Bi S

Peptide YY(3-36) inhibits gastric emptying and produces acute reductions in food intake in rhesus monkeys.

American journal of physiology. Regulatory, integrative and comparative physiology

Moran TH, Smedh U, Kinzig KP, Scott KA, Knipp S, Ladenheim EE